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Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals.
Antonie van Leeuwenhoek ( IF 2.6 ) Pub Date : 2020-06-04 , DOI: 10.1007/s10482-020-01430-5
Jens Möller 1 , Luca Musella 1 , Vyacheslav Melnikov 2 , Walter Geißdörfer 3 , Andreas Burkovski 1 , Vartul Sangal 4
Affiliation  

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.



中文翻译:

对动物致病的新型棒杆菌物种的系统生物学特征。

棒杆菌属包括具有生物技术,医学和兽医学重要性的物种。最近从一头野猪坏死性淋巴结炎病例中分离出一种非典型的溃疡杆菌C25。在这项研究中,我们分析了该菌株的基因组序列,并将其表型和毒力特性与其他棒状杆菌病原体进行了比较。系统进化分析表明,菌株W25与PO100 / 5和KL1196一起属于新物种。后者是分别从猪和a中分离得到的。因此,该物种似乎与动物有关。分离株W25可能是非毒性毒素由于spaBCspaDEF菌毛基因簇中基因功能的潜在丧失,该基因携带菌株可能具有受损的粘附于咽和喉上皮细胞的能力。存在许多棒杆菌毒力基因,包括编码磷脂酶D的pld。因此,该菌株可能能够引起动物的严重侵袭性感染和人的人畜共患感染。

更新日期:2020-07-24
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