The emerging polymer nanocomposites have received industrial interests in diverse fields because of their added value in metal oxide-based nanocomposites, such as titanium (TiO₂) and zinc oxide (ZnO). Linear low-density polyethylene (LLDPE)-based polymer has recently generated a huge market in the healthcare industry. TiO₂ and ZnO are well known for their instant photocatalytic killing of hospital-acquired infections, especially multidrug-resistant (MDR) pathogens. This study investigated the actions of LLDPE/TiO₂/ZnO (1:3) nanocomposites in different weight% against two representative MDR pathogens, namely, methicillin-resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia (K.pneumoniae). Antibacterial activities were quantified according to international standard guidelines of CLSI MO2-A11 (static condition) and ASTM E-2149 (dynamic condition). Preliminary observation via a scanning electron microscope revealed that LLDPE matrix with TiO₂/ZnO nanocomposites changed the bacterial morphology and reduced the bacterial adherence and biofilm formation. Furthermore, a high ZnO weight ratio killed both types of pathogens. The bactericidal potential of the nanocomposite is highlighted by the enhancements in photocatalytic activity, zinc ion release and reactive species, and bacteriostatic/bactericidal activity against bacterial growth. This study provides new insights into the MDR-bactericidal potential of LLDPE with TiO₂/ZnO nanocomposites for targeted healthcare applications.

新兴的聚合物纳米复合材料因其在金属氧化物纳米复合材料（如钛 (TiO ₂ ) 和氧化锌 (ZnO)）中的附加值而在不同领域受到工业界的关注。基于线性低密度聚乙烯 (LLDPE) 的聚合物最近在医疗保健行业产生了巨大的市场。众所周知，TiO ₂和 ZnO 可以立即光催化杀死医院获得性感染，尤其是多重耐药 (MDR) 病原体。本研究调查LLDPE / TiO 2的动作₂ /氧化锌（1：3）在不同的重量％的纳米复合材料对两个代表性MDR病原体，即，耐甲氧西林金黄色葡萄球菌（MRSA）和肺炎克雷伯氏菌（肺炎克雷伯菌）。根据 CLSI MO2-A11（静态条件）和 ASTM E-2149（动态条件）的国际标准指南对抗菌活性进行量化。通过扫描电子显微镜的初步观察表明，含有 TiO ₂ /ZnO 纳米复合材料的LLDPE 基质改变了细菌的形态，减少了细菌的粘附和生物膜的形成。此外，高 ZnO 重量比可以杀死两种类型的病原体。纳米复合材料的杀菌潜力通过光催化活性、锌离子释放和活性物质的增强以及对细菌生长的抑菌/杀菌活性的增强而突出。这项研究为 LLDPE 与 TiO ₂的 MDR 杀菌潜力提供了新的见解/ZnO 纳米复合材料用于有针对性的医疗保健应用。