Controlling angiogenesis within tissue engineered constructs remains a critical challenge, especially with regard to the guidance of pre-vascular network formation. Here, we aimed to regulate angiogenesis on a self-assembled honeycomb nanofibrous scaffold. Scaffolds with honeycombs patterns have several desirable properties for tissue engineering, including large surface area, high structural stability and good permeability. Furthermore, the honeycomb pattern resembles early vascular network formation. The self-assembly electrospinning approach to honeycomb scaffolds is a technically simple, rapid, and direct way to realize selective deposition of nanofibers. To evaluate cell compatibility, spreading, proliferation and tube formation, human umbilical vein endothelial cells (HUVECs) were cultured on honeycomb scaffolds, as well as on random scaffolds for comparison. The optimized honeycomb nanofibrous scaffolds were observed to better support cell proliferation and network format...

中文翻译：

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自组装蜂窝状纳米纤维支架的制备以指导内皮形态发生。

在组织工程构建体中控制血管生成仍然是关键的挑战，特别是在指导血管前网络形成方面。在这里，我们旨在调节自组装蜂窝状纳米纤维支架上的血管生成。具有蜂窝状图案的支架具有用于组织工程的几个理想特性，包括大表面积，高结构稳定性和良好的渗透性。此外，蜂窝状类似于早期的血管网络形成。蜂窝支架的自组装静电纺丝方法是实现纳米纤维选择性沉积的技术上简单，快速且直接的方法。为了评估细胞的相容性，扩散，增殖和管形成，将人脐静脉内皮细胞（HUVEC）培养在蜂窝支架上，以及随机支架进行比较。观察到优化的蜂窝状纳米纤维支架可更好地支持细胞增殖和网络格式。