Onion (Allium cepa) extract was used for the green synthesis of gold and silver nanoparticles. Each colloidal solution exhibited surface plasmon resonance, with a peak at 532 nm for gold nanoparticles and 391 nm for silver nanoparticles. Microscopic results confirmed the presence of spherical shapes. The X-ray diffraction pattern demonstrated a face-centered cubic structure. Both nanoparticles had negative zeta potentials and retained colloidal stability in cell culture medium. Catalytic applications were evaluated for 4-nitrophenol reduction and methyl orange degradation reactions by monitoring with UV-visible spectrophotometry. Furthermore, the nanoparticles demonstrated no significant cytotoxicity against human pancreas ductal adenocarcinoma cells (PANC-1) and human colorectal adenocarcinoma cells (HT-29). PEGylation and diallyl disulphide loading of the gold and silver nanoparticles meaningfully reduced the cell viability of both cell lines. Furthermore, diallyl disulphide loading resulted in more cytotoxicity against PANC-1 cells than against HT-29 cells. Additionally, the gold nanoparticles were more cytotoxic than the silver nanoparticles upon diallyl disulphide loading. Interestingly, after PEGylation and diallyl disulphide loading, the silver nanoparticles exhibited acorn-like shapes, while the gold nanoparticles retained spherical shapes. This result suggested that nanoparticles green-synthesised by onion extract have possibilities as nanocatalysts and drug delivery nanocarriers for catalytic and nanomedicine applications.

中文翻译：

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使用洋葱提取物合成的负载二烯丙基二硫化物的球形金纳米颗粒和橡子状银纳米颗粒：催化活性和细胞毒性。

洋葱（洋葱）的提取物用于金和银纳米粒子的绿色合成。每种胶体溶液均表现出表面等离振子共振，对于金纳米颗粒，在532 nm处具有峰值，对于银纳米颗粒，在391 nm处具有峰值。微观结果证实存在球形。X射线衍射图显示出面心立方结构。两种纳米颗粒均具有负的ζ电势，并在细胞培养基中保留了胶体稳定性。通过用紫外可见分光光度法监测，评估了催化应用中的4-硝基苯酚还原反应和甲基橙降解反应。此外，纳米颗粒对人胰腺导管腺癌细胞（PANC-1）和人结肠直肠腺癌细胞（HT-29）没有明显的细胞毒性。金和银纳米颗粒的聚乙二醇化和二烯丙基二硫化物负载显着降低了两种细胞系的细胞活力。此外，二烯丙基二硫化物上样导致对PANC-1细胞的细胞毒性大于对HT-29细胞的细胞毒性。另外，在负载二烯丙基二硫化物时，金纳米颗粒比银纳米颗粒更具细胞毒性。有趣的是，在聚乙二醇化和二烯丙基二硫化物负载后，银纳米颗粒表现出橡子状的形状，而金纳米颗粒保持球形。该结果表明，由洋葱提取物绿色合成的纳米颗粒具有作为用于催化剂和纳米医学应用的纳米催化剂和药物递送纳米载体的可能性。二烯丙基二硫化物上样导致对PANC-1细胞的细胞毒性大于对HT-29细胞的细胞毒性。另外，在负载二烯丙基二硫化物时，金纳米颗粒比银纳米颗粒更具细胞毒性。有趣的是，在聚乙二醇化和二烯丙基二硫化物负载后，银纳米颗粒表现出橡子状的形状，而金纳米颗粒保持球形。该结果表明，由洋葱提取物绿色合成的纳米颗粒具有作为用于催化剂和纳米医学应用的纳米催化剂和药物递送纳米载体的可能性。二烯丙基二硫化物上样导致对PANC-1细胞的细胞毒性大于对HT-29细胞的细胞毒性。另外，在负载二烯丙基二硫化物时，金纳米颗粒比银纳米颗粒更具细胞毒性。有趣的是，在聚乙二醇化和二烯丙基二硫化物负载后，银纳米颗粒表现出橡子状的形状，而金纳米颗粒保持球形。该结果表明，由洋葱提取物绿色合成的纳米颗粒具有作为用于催化剂和纳米医学应用的纳米催化剂和药物递送纳米载体的可能性。聚乙二醇化和二烯丙基二硫化物上样后，银纳米颗粒呈现橡子状，而金纳米颗粒保留球形。该结果表明，由洋葱提取物绿色合成的纳米颗粒具有作为用于催化剂和纳米医学应用的纳米催化剂和药物递送纳米载体的可能性。聚乙二醇化和二烯丙基二硫化物上样后，银纳米颗粒呈现橡子状，而金纳米颗粒保留球形。该结果表明，由洋葱提取物绿色合成的纳米颗粒具有作为用于催化剂和纳米医学应用的纳米催化剂和药物递送纳米载体的可能性。