Background: miR-4293 rs12220909 polymorphism was reported associated with tumorigenesis, but the results are controversial. Thus, we planned to verify and obtain precise results.Methods: Databases were searched and reviewed up to November, 2019. Case-control studies which concern about the association between cancer risks and miR-4293 polymorphisms were all enrolled. The odds ratios (ORs) and 95% confidence intervals (CIs) calculated by the Z test were used to assess the underlying links. We also prospected how the miR-4293 impacts biological process through its target genes.Result: Finally, there are seven independent studies meet the enrolled criteria, along with 5147 cases and 6108 healthy controls. We revealed that there is a significant decrease effect of miR-4293 rs12220909 to cancer risks in heterozygote genetic model (BA vs. AA: OR = 0.857, p = .032), the similar results were also uncovered in PB control group, lung cancer and the studies conform to HWE. Results from GO items and KEGG pathway analysis illustrated that myeloid cell development, transcription factor complex, RNA polymerase II regulatory region DNA binding were regulated by miR-4293.Conclusion: In summary, our meta-analysis chase down heterozygote rs12220909 polymorphism of miR-4293 is a protective factor to cancer initiation, especially for lung cancer.

中文翻译：

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miR-4293 rs12220909变体是否影响癌症易感性：来自11255名受试者的证据。

背景：据报道miR-4293 rs12220909基因多态性与肿瘤发生有关，但结果存在争议。因此，我们计划验证并获得准确的结果。方法：检索和审查数据库直至2019年11月。所有病例研究均关注癌症风险与miR-4293多态性之间的关系。Z检验计算的比值比（OR）和95％置信区间（CI）用于评估基础链接。我们还探究了miR-4293如何通过其靶基因影响生物过程。结果：最后，有7项符合入选标准的独立研究，以及5147例病例和6108例健康对照。我们发现，在杂合子遗传模型中，miR-4293 rs12220909对癌症风险有显着的降低作用（BA对AA：OR = 0.857，p = .032），PB对照组，肺癌患者也未发现类似结果，且研究符合HWE。GO项和KEGG通路分析的结果表明miR-4293调节了髓样细胞的发育，转录因子复合体，RNA聚合酶II调控区DNA的结合。是引发癌症的保护因素，尤其是对于肺癌。