ABSTRACT In recent years remarkable efforts have been made to produce artificial bone through tissue engineering techniques. Silk fibroin (SF) and hydroxyapatite (HA) have been used in bone tissue regeneration as biomaterials due to mechanical properties of SF and biocompatibility of HA. There has been growing interest in developing SF/HA composites to reduce bone defects. In this regard, several attempts have been made to study the biocompatibility and osteoconductive properties of this material. This article overviews the recent advance from last few decades in terms of the preparative methods and application of SF/HA in bone regeneration. Its first part is related to SF that presents the most common sources, preparation methods and comparison of SF with other biomaterials. The second part illustrates the importance of HA by providing information about its production and properties. The third part presents comparative studies of SF/HA composites with different concentrations of HA along with methods of preparation of composites and their applications.

中文翻译：

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丝素蛋白/羟基磷灰石支架：一种高度相容的骨再生材料

摘要 近年来，通过组织工程技术生产人造骨已经做出了显着的努力。由于丝素蛋白 (SF) 和羟基磷灰石 (HA) 的机械性能和 HA 的生物相容性，已将丝素蛋白 (SF) 和羟基磷灰石 (HA) 作为生物材料用于骨组织再生。人们对开发 SF/HA 复合材料以减少骨缺损越来越感兴趣。在这方面，已经进行了多次尝试来研究这种材料的生物相容性和骨传导特性。本文概述了过去几十年在 SF/HA 在骨再生中的制备方法和应用方面的最新进展。它的第一部分与SF有关，介绍了SF与其他生物材料的最常见来源、制备方法和比较。第二部分通过提供有关其生产和特性的信息来说明 HA 的重要性。第三部分介绍了具有不同 HA 浓度的 SF/HA 复合材料的比较研究以及复合材料的制备方法及其应用。