Periodontitis is an inflammatory disease involving complex tripartite cross-interactions among bacterial, host and environment factors. Heat shock proteins (Hsps) are a protein family produced in response to stress conditions. Hsps protect cells under adverse circumstances such as infection, inflammation and disease. One of the causes of periodontal disease is thought to be an imbalance in the expression of Hsps and anti-Hsp antibodies. Hsps are classified according to their molecular weight, and one of the major ones is Hsp70. In the present study, enzyme-linked immunosorbent assay was used to measure the levels of anti-Hsp70 antibody in gingival crevicular fluid (GCF) from two gingival sulci in each of nine patients with chronic periodontitis (CP): one healthy control (HC) site with a probing pocket depth (PPD) of ≤3 mm and one CP site with a PPD of >5 mm. Anti-Hsp70 antibody levels in GCF were higher at HC sites than at CP sites. Moreover, the anti-Hsp70 antibody levels were found to increase after initial periodontal therapy at both HC and CP sites. These results suggest an association of anti-Hsp70 antibody with periodontitis.

牙周炎是一种炎症性疾病，涉及细菌，宿主和环境因素之间复杂的三方交叉相互作用。热激蛋白（Hsps）是响应压力条件而产生的蛋白家族。Hsps在诸如感染，炎症和疾病等不利情况下保护细胞。牙周疾病的原因之一被认为是Hsps和抗Hsp抗体表达的失衡。Hsps根据其分子量进行分类，其中主要的一种是Hsp70。在本研究中，使用酶联免疫吸附法测定了9例慢性牙周炎（CP）患者中每两个龈沟中龈沟液（GCF）中抗Hsp70抗体的水平：1个健康对照（HC）部位，探测袋深度（PPD）≤3 mm，1个CP部位，PPD> 5 mm。GCF中的抗Hsp70抗体水平在HC位点高于在CP位点。此外，发现最初的牙周治疗后，HC和CP部位的抗Hsp70抗体水平均升高。这些结果表明抗Hsp70抗体与牙周炎有关。