Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium's cytocompatibility, discs of UG and CG titanium were fabricated with controlled texture and roughness. The discs were seeded with MC3T3-E1 pre-osteoblastic cells and cultured for 72 h. The proliferation of cells on polished UG-Ti exceeded unpolished CG-Ti 3.04-fold. Cell proliferation was found to correlate with a new biophysical parameter, the average grain boundary length per surface-attached cell.

中文翻译：

---

表面晶界密度对钛前成骨细胞增殖的影响。

自2004年以来的研究表明，超细颗粒（UG）商业纯度（CP）钛的细胞相容性比粗颗粒（CG）CP钛（Ti）的细胞相容性高30％至20倍。为了隔离影响CP钛细胞相容性这种较大报道变异性的因素，制造了具有受控纹理和粗糙度的UG和CG钛圆盘。将圆盘接种MC3T3-E1成骨前细胞，培养72小时。抛光的UG-Ti上的细胞增殖超过未抛光的CG-Ti 3.04倍。发现细胞增殖与新的生物物理参数相关，即每个表面附着的细胞的平均晶界长度。