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The soluble sperm factor that activates the egg: PLCzeta and beyond
Reproduction ( IF 3.8 ) Pub Date : 2020-07-01 , DOI: 10.1530/rep-20-0079
Karl Swann 1
Affiliation  

PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs.

中文翻译:

激活卵子的可溶性精子因子:PLCzeta 及其他

PLCzeta(ζ) 在哺乳动物受精时启动 Ca2+ 振荡和卵子活化,但对由 PLCζ 敲除 (KO) 精子受精的小鼠卵子的研究表明,还有另一个缓慢作用因素导致 Ca2+ 释放。在这里,我提出了一个关于第二个精子因子如何导致小鼠卵子中 Ca2+ 振荡的假设。
更新日期:2020-07-01
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