Bone is a critically important part of the skeletal system that is essential for body support and locomotion. The immune system protects against pathogens and is active in host defense. These two seemingly distinct systems in fact interact with each other, share molecules and create a collaborative regulatory system called the "osteoimmune system". The most representative osteoimmune molecule is receptor activator of NF-κB ligand (RANKL), which plays multiple roles in the osteoimmune system under both physiological and pathological conditions such as rheumatoid arthritis and cancer metastasis to bone. Based on accumulating evidence for such mutual dependence, it is concluded that the relationship between bone and the immune system did not develop by accident but as a necessary consequence of evolution. Here I describe the history of and recent advances in osteoimmunology, providing a perspective in the contexts of both science and medicine.

中文翻译：

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骨免疫学-双向对话和骨骼与免疫领域的必然结合。

骨骼是骨骼系统的重要组成部分，对于身体的支撑和运动至关重要。免疫系统可以抵抗病原体，并在宿主防御中发挥积极作用。这两个看似截然不同的系统实际上彼此相互作用，共享分子并创建一个称为“骨免疫系统”的协同调节系统。最具代表性的骨免疫分子是NF-κB配体的受体激活剂（RANKL），在类风湿性关节炎和癌症转移至骨骼等生理和病理条件下，骨免疫系统中都扮演着多种角色。基于这种相互依赖的积累证据，可以得出结论，骨骼与免疫系统之间的关系不是偶然发生的，而是进化的必然结果。