The mouse preimplantation embryo is a paradigm for discovery of the molecular principles governing formation of specific cell types during development. In this Point of View Article, we show that conditions commonly used for ex vivo culture of preimplantation development are themselves antagonistic to a pathway that is critical for blastocyst lineage commitment.

中文翻译：

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培养条件拮抗小鼠胚泡中的谱系促进信号

小鼠植入前胚胎是发现在发育过程中控制特定细胞类型形成的分子原理的范例。在这篇观点文章中，我们展示了通常用于植入前发育的离体培养的条件本身与对囊胚谱系承诺至关重要的途径相反。