Recounts how our collaboration with Nick Martin was shaped over two decades, leading to the first studies of predictions from the ‘Dual Route Cascaded’ computational model of reading in twins, and extending into the molecular work, first linkage, fine mapping of genes identified in pedigree studies, into now the genomewide association study era and the first polygenic risk scores for reading and their potential in early clarifying causality and validating interventions, as well as for future global collaborations in improving these predictors and identifying causal variants. We highlight Nick’s warm, future-focused optimism, support and inclusive approach without which none of this would have been possible. The circle of Nick asking, over half a century ago, ‘What genes do you think make some kids get better grades?’ has built a diverse scientific legacy involving thousands of papers and collaborations. The (heritable) traits of curiosity, boldness, warmth, interest in societally important questions, openness to new methods, ambition and collaborative skill to bring into being the infrastructure and samples needed for this research are rare, and we are grateful.

中文翻译：

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阅读和语言的遗传学

讲述了我们与尼克·马丁的合作是如何在 20 年中形成的，导致对双胞胎阅读的“双路径级联”计算模型的预测进行首次研究，并扩展到分子工作、第一次连锁、在谱系研究，到现在的全基因组关联研究时代和第一个阅读多基因风险评分及其在早期澄清因果关系和验证干预措施方面的潜力，以及未来在改进这些预测因子和识别因果变异方面的全球合作。我们强调尼克热情、着眼于未来的乐观、支持和包容的态度，如果没有这些，这一切都是不可能的。半个多世纪前，尼克的圈子问，“你认为是什么基因让一些孩子取得了更好的成绩？” 建立了涉及数千篇论文和合作的多样化科学遗产。好奇心、大胆、热情、对社会重要问题的兴趣、对新方法的开放性、雄心和协作技能等（可遗传的）特征很少见，我们很感激。