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Mining the jewels of the cortex's crowning mystery.
Current Opinion in Neurobiology ( IF 5.7 ) Pub Date : 2020-05-29 , DOI: 10.1016/j.conb.2020.04.005 Leena A Ibrahim 1 , Ben Schuman 2 , Rachel Bandler 3 , Bernardo Rudy 2 , Gord Fishell 4
Current Opinion in Neurobiology ( IF 5.7 ) Pub Date : 2020-05-29 , DOI: 10.1016/j.conb.2020.04.005 Leena A Ibrahim 1 , Ben Schuman 2 , Rachel Bandler 3 , Bernardo Rudy 2 , Gord Fishell 4
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Neocortical Layer 1 consists of a dense mesh of excitatory and inhibitory axons, dendrites of pyramidal neurons, as well as neuromodulatory inputs from diverse brain regions. Layer 1 also consists of a sparse population of inhibitory interneurons, which are appropriately positioned to receive and integrate the information from these regions of the brain and modulate cortical processing. Despite being among the sparsest neuronal population in the cortex, Layer 1 interneurons perform powerful computations and have elaborate morphologies. Here we review recent studies characterizing their origin, morphology, physiology, and molecular profiles, as well as their connectivity and in vivo response properties.
中文翻译:
挖掘皮质最高神秘的珠宝。
新皮质层1由密集的兴奋性和抑制性轴突,锥体神经元树突以及来自不同大脑区域的神经调节输入组成。第1层还包含稀疏的抑制性中间神经元,这些中间神经元的位置适当,可以接收和整合来自大脑这些区域的信息并调节皮层处理。尽管属于皮层中最稀疏的神经元种群之一,第1层中间神经元仍能执行强大的计算并具有复杂的形态。在这里,我们审查最近表征其起源,形态,生理和分子概况,以及它们的连接性和体内反应特性的研究。
更新日期:2020-05-29
中文翻译:
挖掘皮质最高神秘的珠宝。
新皮质层1由密集的兴奋性和抑制性轴突,锥体神经元树突以及来自不同大脑区域的神经调节输入组成。第1层还包含稀疏的抑制性中间神经元,这些中间神经元的位置适当,可以接收和整合来自大脑这些区域的信息并调节皮层处理。尽管属于皮层中最稀疏的神经元种群之一,第1层中间神经元仍能执行强大的计算并具有复杂的形态。在这里,我们审查最近表征其起源,形态,生理和分子概况,以及它们的连接性和体内反应特性的研究。