BACKGROUND Cladribine is an antimetabolite used for the treatment of relapsing-remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk. OBJECTIVE We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose. METHODS Analysis was done using liquid chromatography-mass spectrometry. RESULTS The relative infant dose calculated in this study was 3.06%. CONCLUSION This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.

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克拉屈滨转移到母乳中：病例报告

背景技术克拉屈滨是一种用于治疗复发缓解型多发性硬化症的抗代谢药。目前，尚无有关其在母乳喂养母亲中使用以及在母乳中转移的数据。目的 我们介绍了一位哺乳期母亲的病例，她捐献了她的乳汁样本，以研究克拉屈滨口服 20 毫克剂量后的转移。方法 使用液相色谱-质谱法进行分析。结果本研究计算的婴儿相对剂量为3.06%。结论 这是第一份表明克拉屈滨在母乳中发生可检测量转移的病例报告。然而，哺乳期间应谨慎。