A three-component synthesis of multisubstituted fluorene derivatives has been developed by devising a rhodium-catalyzed stitching reaction/remote nucleophilic substitution sequence. A variety of nucleophiles can be installed in the second step including both heteroatom and carbon nucleophiles. An efficient synthesis of 5H-benzo[a]fluoren-5-ones has also been realized using N-(2-alkynyl)benzoylpyrrole as the reaction partner through a new reaction pathway.

中文翻译：

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铑催化的缝合反应/远程亲核取代序列的分子间三组分合成芴衍生物。

通过设计铑催化的拼接反应/远程亲核取代序列，已经开发了多取代芴衍生物的三组分合成方法。第二步中可以安装各种亲核试剂，包括杂原子亲核试剂和碳亲核试剂。N-（2-炔基）苯甲酰基吡咯通过新的反应路径作为反应伙伴，也已经实现了5 H-苯并[ a ]芴-5-酮的高效合成。