Objectives To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants. Design Prospective national population based cohort study using the UK Obstetric Surveillance System (UKOSS). Setting All 194 obstetric units in the UK. Participants 427 pregnant women admitted to hospital with confirmed SARS-CoV-2 infection between 1 March 2020 and 14 April 2020. Main outcome measures Incidence of maternal hospital admission and infant infection. Rates of maternal death, level 3 critical care unit admission, fetal loss, caesarean birth, preterm birth, stillbirth, early neonatal death, and neonatal unit admission. Results The estimated incidence of admission to hospital with confirmed SARS-CoV-2 infection in pregnancy was 4.9 (95% confidence interval 4.5 to 5.4) per 1000 maternities. 233 (56%) pregnant women admitted to hospital with SARS-CoV-2 infection in pregnancy were from black or other ethnic minority groups, 281 (69%) were overweight or obese, 175 (41%) were aged 35 or over, and 145 (34%) had pre-existing comorbidities. 266 (62%) women gave birth or had a pregnancy loss; 196 (73%) gave birth at term. Forty one (10%) women admitted to hospital needed respiratory support, and five (1%) women died. Twelve (5%) of 265 infants tested positive for SARS-CoV-2 RNA, six of them within the first 12 hours after birth. Conclusions Most pregnant women admitted to hospital with SARS-CoV-2 infection were in the late second or third trimester, supporting guidance for continued social distancing measures in later pregnancy. Most had good outcomes, and transmission of SARS-CoV-2 to infants was uncommon. The high proportion of women from black or minority ethnic groups admitted with infection needs urgent investigation and explanation. Study registration ISRCTN 40092247.

中文翻译：

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英国确诊 SARS-CoV-2 感染入院孕妇的特征和结果：基于国家人群的队列研究。

目的 描述英国因严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染入院的全国孕妇队列，确定与感染相关的因素，并描述母婴结局，包括感染传播. 使用英国产科监测系统 (UKOSS) 设计前瞻性全国人群队列研究。设置英国所有 194 个产科单位。参与者 2020 年 3 月 1 日至 2020 年 4 月 14 日期间因确诊 SARS-CoV-2 感染入院的 427 名孕妇。主要结局指标 产妇住院和婴儿感染的发生率。孕产妇死亡率、3 级重症监护病房入院率、流产率、剖腹产率、早产率、死产率、新生儿早期死亡率和新生儿病房入院率。结果 妊娠期间确诊 SARS-CoV-2 感染入院的估计发病率为每 1000 名产妇 4.9（95% 置信区间 4.5 至 5.4）。233 名（56%）怀孕期间因 SARS-CoV-2 感染入院的孕妇来自黑人或其他少数民族，281 名（69%）超重或肥胖，175 名（41%）年龄在 35 岁或以上，以及145 (34%) 人有既往合并症。266 (62%) 名妇女分娩或流产；196 (73%) 人足月分娩。入院的四十一名 (10%) 妇女需要呼吸支持，五名 (1%) 妇女死亡。265 名婴儿中有 12 名 (5%) 的 SARS-CoV-2 RNA 检测呈阳性，其中 6 名是在出生后的前 12 小时内检测到的。结论 大多数因 SARS-CoV-2 感染入院的孕妇处于妊娠中期或晚期，支持在怀孕后期继续保持社交距离措施的指导。大多数都有良好的结果，SARS-CoV-2 传播给婴儿的情况并不常见。黑人或少数民族女性被确诊感染的比例很高，需要紧急调查和解释。研究注册 ISRCTN 40092247。