Among potent dietary supplements, Momordica charantia, commonly called bitter melon, has various biological effects, such as antioxidant and anti-inflammatory effects, and improves energy metabolism and fatigue recovery. However, it is unknown whether Momordica charantia extract (MCE) induces antifatigue effects during exercise training in high-temperature environments. This study aimed at investigating the efficacy of MCE by examining 10 male tennis players consuming 100 mL MCE/dose (6 times a day over 4 weeks) during the summer training season. Peripheral (ammonia and uric acid) and central (serotonin, dopamine, and prolactin) fatigue parameters were measured before and after MCE consumption; before, during, and after exercise; and the next morning. After consuming MCE supplements, ammonia levels were higher during and after exercise and recovered the next morning, whereas uric acid levels did not change at any time point. Serotonin levels were lower during exercise. Dopamine levels were higher, especially during exercise. Prolactin levels were lower at all time points, especially during and after exercise. Although high-intensity training in a hot environment causes accumulation of fatigue-related metabolites, our results indicate that 4 weeks of MCE intake positively influenced fatigue parameters, suggesting that MCE can efficiently combat fatigue.

中文翻译：

---

高温下高强度训练运动员外围和中枢疲劳的潜在生物标志物：苦瓜（苦瓜）的初步研究。

在有效的膳食补充剂中，苦瓜（Morordica charantia），通常称为苦瓜，具有多种生物学作用，例如抗氧化和消炎作用，并改善能量代谢和疲劳恢复。但是，苦瓜是否为charantia尚不清楚提取物（MCE）在高温环境下的运动训练过程中会引起抗疲劳作用。这项研究旨在通过检查10名男性网球运动员在夏季训练季节期间消耗100 mL MCE /剂量（4周内每天6次）来研究MCE的功效。在服用MCE之前和之后测量周围（氨和尿酸）和中央（血清素，多巴胺和催乳素）的疲劳参数；运动前，运动中和运动后；第二天早上 服用MCE补充剂后，运动期间和运动后的氨水平更高，第二天早晨恢复，而尿酸水平在任何时间都没有变化。运动过程中血清素水平较低。多巴胺水平较高，尤其是在运动过程中。催乳素水平在所有时间点均较低，尤其是在运动期间和运动后。