Inhibitory control is crucial for regulating emotions and may also enable memory control. However, evidence for their shared neurobiological correlates is limited. Here, we report meta-analyses of neuroimaging studies on emotion regulation, or memory control and link neural commonalities to transcriptional commonalities using the Allen Human Brain Atlas (AHBA). Based on 95 functional magnetic resonance imaging studies, we reveal a role of the right inferior parietal lobule embedded in a frontal–parietal–insular network during emotion regulation and memory control, which is similarly recruited during response inhibition. These co-activation patterns also overlap with the networks associated with ‘inhibition’, ‘cognitive control’ and ‘working memory’ when consulting the Neurosynth. Using the AHBA, we demonstrate that emotion regulation- and memory control-related brain activity patterns are associated with transcriptional profiles of a specific set of ‘inhibition-related’ genes. Gene ontology enrichment analysis of these ‘inhibition-related’ genes reveal associations with the neuronal transmission and risk for major psychiatric disorders as well as seizures and alcoholic dependence. In summary, this study identified a neural network and a set of genes associated with inhibitory control across emotion regulation and memory control. These findings facilitate our understanding of the neurobiological correlates of inhibitory control and may contribute to the development of brain stimulation and pharmacological interventions.

中文翻译：

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抑制控制的常见神经和转录相关因素是情绪调节和记忆控制的基础。

抑制性控制对于调节情绪至关重要，也可以实现记忆控制。但是，它们共享的神经生物学相关性的证据有限。在这里，我们报告神经成像研究对情绪调节或记忆控制的荟萃分析，并使用艾伦人脑图集（AHBA）将神经共性与转录共性联系起来。基于95项功能磁共振成像研究，我们揭示了在情绪调节和记忆控制过程中嵌入在额叶顶壁-岛状网络中的右下壁小叶的作用，在抑制反应时也同样如此。在咨询Neurosynth时，这些共激活模式也与与“抑制”，“认知控制”和“工作记忆”相关的网络重叠。使用AHBA，我们证明情绪调节和记忆控制相关的大脑活动模式与一组特定的“抑制相关”基因的转录谱相关。这些“抑制相关”基因的基因本体富集分析揭示了与神经元传递和重大精神疾病以及癫痫发作和酒精依赖相关的风险。总而言之，这项研究确定了一个神经网络和一组与情绪调节和记忆控制中的抑制控制相关的基因。这些发现促进了我们对抑制控制的神经生物学相关性的理解，并可能有助于大脑刺激和药物干预的发展。