In vitro gut fermentation models were firstly introduced in nutrition and applied microbiology research back in the nineties. These models have improved greatly during time, mainly over the resemblance to the complexity of digestion stages, the replication of experimental conditions, the multitude of ecological parameters to assay. The state of the science is that the most competitive models shall include a complex gut microbiota, small working volumes, distinct interconnected compartments, and rigorous bio-chemical and ecological settings, controlled by a computer, as well as a free-hands accessibility, not to contaminate the mock microbiota.

中文翻译：

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肠道发酵体外模型研究食物诱导的肠道菌群转移：最新综述。

体外肠道发酵模型最早于90年代被引入营养和应用微生物学研究。这些模型在时间上有了很大的改进，主要是在类似于消化阶段的复杂性，实验条件的重复以及要分析的众多生态参数上。科学的状态是，最具竞争力的模型应包括复杂的肠道菌群，较小的工作量，相互独立的隔间以及严格的生化和生态环境（由计算机控制）以及徒手可及性，而非污染模拟菌群。