Polysaccharide-based nanoparticles such as pectin had always been of greatest interest because of its excellent solubility and mucoadhesive nature and are highly suitable for oral drug delivery for drug administration. In this study, we used commercially available pectin samples based on their degree of esterification, and nanoparticles were fabricated by the ionotropic gelation method using magnesium (Mg2+) as the divalent cross-linker. We conducted a comparative analysis on the three pectin NPs—high methoxylated pectin (HMP), low methoxylated pectin (LMP), and amidated LMP (AMP)—to examine the difference in characteristics such as shape, size, and biocompatibility. HMP and AMP were found to be similar in size (~850 nm), whereas LMP was found to be of ~700 nm. The three NPs were also tested for their biocompatibility toward THP-1 cells. All three NPs were found to have the potential as a nanocarrier of therapeutic and preventive drugs, especially through oral routes.

基于多糖的纳米颗粒（如果胶）一直以来一直是最受关注的，因为它具有出色的溶解性和粘膜粘附性，非常适合用于药物给药的口服药物递送。在这项研究中，我们根据酯化程度使用了市售的果胶样品，并使用镁（Mg 2+）作为二价交联剂。我们对三种果胶NP（高甲氧基化果胶（HMP），低甲氧基化果胶（LMP）和酰胺化LMP（AMP））进行了比较分析，以检验形状，大小和生物相容性等特性的差异。发现HMP和AMP的大小相似（约850 nm），而LMP约为700 nm。还测试了这三个NP对THP-1细胞的生物相容性。发现所有这三种NP都具有作为治疗和预防药物的纳米载体的潜力，尤其是通过口服途径。