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Long term results after surgical resection of peritoneal metastasis from neuroendocrine tumors.
Neuroendocrinology ( IF 4.1 ) Pub Date : 2020-06-08 , DOI: 10.1159/000509220 Léonor Benhaim 1 , Matthieu Faron 2, 3 , Julien Hadoux 4 , Maximiliano Gelli 2 , Isabelle Sourrouille 2 , Pascal Burtin 5 , Charles Honoré 2 , David Malka 5 , Sophie Leboulleux 4 , Michel Ducreux 5 , Jean-Yves Scoazec 4 , Diane Goere 2 , Eric Baudin 4
Neuroendocrinology ( IF 4.1 ) Pub Date : 2020-06-08 , DOI: 10.1159/000509220 Léonor Benhaim 1 , Matthieu Faron 2, 3 , Julien Hadoux 4 , Maximiliano Gelli 2 , Isabelle Sourrouille 2 , Pascal Burtin 5 , Charles Honoré 2 , David Malka 5 , Sophie Leboulleux 4 , Michel Ducreux 5 , Jean-Yves Scoazec 4 , Diane Goere 2 , Eric Baudin 4
Affiliation
Introduction: Peritoneal metastases from neuroendocrine tumors are associated with bad prognosis. The objective of our study was to evaluate whether surgical resection could lead to prolonged survival in selected patients. This survival was compared to that of patients operated for liver metastasis. Methods: From our prospectively maintain database we included 88 patients who underwent the complete resection of peritoneal and/or liver metastasis between January 1995 and December 2016 in Gustave-Roussy. Three groups of resection were compared: peritoneal metastasis alone, liver metastasis alone and the combined resection of liver and peritoneal metastases.
Results: The median peritoneal cancer index was 10 in the peritoneal group and 11 in the peritoneal + liver group. The 5-year overall survival was 81% [60-100] in the peritoneal group compared to 78% [65.2-92.8] in the liver group, and 72% [58.7-89.7] in the peritoneal + liver group (p=0.71). The 3-years disease free survival reached 26.9% [16.1-45.1] in the liver group, 12.5% [2.3-68.2] in the peritoneal group and 32.4% [19.9-52.6] in the combined liver + peritoneal group (p=0.45). In the univariate analysis, the prognosis factors for a longer survival were: small bowel primary tumor origin, low pre-operative CgA level and tumor grade ≤1.
Conclusion: Despite a high recurrence rate, long term overall survival can be achieved after resection of peritoneal metastasis in selected patients. This survival is comparable to that of patients operated for liver metastasis only. Surgery should stand as a standard treatment peritoneal metastases in patients with resectable disease.
中文翻译:
神经内分泌肿瘤腹膜转移手术切除后的长期结果。
简介:神经内分泌肿瘤的腹膜转移与不良预后相关。我们研究的目的是评估手术切除是否可以延长选定患者的生存期。该存活率与肝转移手术患者的存活率进行了比较。方法:从我们前瞻性维护的数据库中,我们纳入了 1995 年 1 月至 2016 年 12 月在 Gustave-Roussy 进行的腹膜和/或肝转移完全切除术的 88 名患者。比较了三组切除术:单纯腹膜转移瘤、单纯肝转移瘤和肝腹膜转移瘤联合切除。结果:腹膜组中位腹膜癌指数为10,腹膜+肝组为11。
更新日期:2020-06-08
中文翻译:
神经内分泌肿瘤腹膜转移手术切除后的长期结果。
简介:神经内分泌肿瘤的腹膜转移与不良预后相关。我们研究的目的是评估手术切除是否可以延长选定患者的生存期。该存活率与肝转移手术患者的存活率进行了比较。方法:从我们前瞻性维护的数据库中,我们纳入了 1995 年 1 月至 2016 年 12 月在 Gustave-Roussy 进行的腹膜和/或肝转移完全切除术的 88 名患者。比较了三组切除术:单纯腹膜转移瘤、单纯肝转移瘤和肝腹膜转移瘤联合切除。结果:腹膜组中位腹膜癌指数为10,腹膜+肝组为11。