Abstract A novel full bio-based ketone-containing aliphatic polyester was prepared by enzyme-catalyzed polycondensation of diethyl γ-ketopimelate (DEK) with 1,6-hexanediol (HDO) using immobilized lipase B from Candida antarctica (CALB). The influences of polymerization conditions such as temperature, time, enzyme amount, and solvent amount on the molecular weight of poly(hexamethylene γ-ketopimelate) (PHK) were investigated. New fully bio-based poly(hexamethylene γ-ketopimelate-co-hexamethylene adipate) (poly(HK-co-HA)) copolymers with narrow polydispersity and well-defined composition were synthesized by copolymerization of DEK, HDO, and diethyl adipate. The structures of PHK and poly(HK-co-HA) copolymers were characterized by nuclear magnetic resonance, and their thermal characterization was examined by thermogravimetric analysis and differential scanning calorimetry. The degradation of PHK and poly(HK-co-HA) copolymers was studied. The post-polymerization modification of these polyketoesters via oxime click chemistry was further demonstrated. Graphical Abstract

中文翻译：

---

新的全生物基聚（六亚甲基γ-酮庚二酸酯）和聚（六亚甲基γ-酮庚二酸酯-共-己二酸己二酸酯）共聚酯的脂肪酶催化合成和聚合后改性

摘要 利用南极念珠菌(CALB) 的固定化脂肪酶B，通过γ-酮庚二酸二乙酯(DEK) 与1,6-己二醇(HDO) 的酶催化缩聚反应制备了一种新型全生物基含酮脂肪族聚酯。考察了聚合条件如温度、时间、酶用量、溶剂用量等对聚六亚甲基γ-酮庚二酸酯(PHK)分子量的影响。通过 DEK、HDO 和己二酸二乙酯的共聚，合成了具有窄多分散性和明确组成的新型全生物基聚（六亚甲基 γ-酮基庚二酸酯-共六亚甲基己二酸酯）（聚（HK-co-HA））共聚物。PHK和聚（HK-co-HA）共聚物的结构通过核磁共振表征，并通过热重分析和差示扫描量热法检查它们的热特性。研究了 PHK 和聚 (HK-co-HA) 共聚物的降解。进一步证明了通过肟点击化学对这些聚酮酯的聚合后改性。图形概要