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Treating post-dengue mania: Is role of valproate and quetiapine related to histone deacetylase inhibition?
Bipolar Disorders ( IF 5.4 ) Pub Date : 2020-06-08 , DOI: 10.1111/bdi.12948
Damodharan Dinakaran 1 , Varshitha Tholasappa 1 , Tshering Lhamu 1 , Vanteemar S Sreeraj 1 , Ganesan Venkatasubramanian 1
Affiliation  

Dengue is a tropical arboviral infection associated with inducing mania in a few cases. Flaviviridae (including Dengue virus)with itsepigenetic influences throughhistone deacetylase (HDAC) may lead to symptom manifestations. Valproate and quetiapine have HDAC inhibitory property and may have pathophysiologically relevant effects in curtailing these symptoms.

中文翻译:

登革热后躁狂症的治疗:丙戊酸和喹硫平的作用与组蛋白脱乙酰基酶抑制作用有关吗?

登革热是一种热带狂犬病毒病毒感染,在少数情况下会引起躁狂。黄病毒科病毒(包括登革热病毒)通过组蛋白脱乙酰基酶(HDAC)的表观遗传学影响可能导致症状表现。丙戊酸盐和喹硫平具有HDAC抑制特性,在减少这些症状时可能具有病理生理学相关作用。
更新日期:2020-06-08
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