The cytokines of the interleukin (IL) -1 family act in the initiation of an effective immune response in Leishmania infection, represented mainly by the T helper 1 (Th1) profile, in addition to being associated with disease exacerbation and controversial contributions in the Th2 responses. The family also includes members who self-regulate inflammation, such as antagonists and anti-inflammatory cytokines, most of which have not yet been studied in Cutaneous Leishmaniasis (CL) in humans. Here we summarize findings about what is known so far about the role of these cytokines in mice, the main study model, and in humans. We reinforce the importance of studies of these cytokines as new targets in the context of CL.

白细胞介素 (IL) -1 家族的细胞因子在利什曼原虫感染中启动有效的免疫反应，主要以 T 辅助 1 (Th1) 谱为代表，此外还与疾病恶化和 Th2 中的有争议的贡献有关回应。该家族还包括自我调节炎症的成员，例如拮抗剂和抗炎细胞因子，其中大部分尚未在人类皮肤利什曼病 (CL) 中进行研究。在这里，我们总结了迄今为止关于这些细胞因子在小鼠、主要研究模型和人类中的作用的已知发现。我们强调将这些细胞因子作为 CL 背景下的新靶点进行研究的重要性。