Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, unusually large RNA genome, and unique replication capability. CoVs are known to cause various potentially lethal human respiratory infectious diseases, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the very recent coronavirus disease 2019 (COVID-19) outbreak. Unfortunately, neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs. Therefore, effective prevention and treatment medications against human coronavirus are in urgent need. In the past decades, many natural compounds have been reported to possess multiple biological activities, including antiviral properties. In this article, we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS, and discussed their potential use for the treatment of COVID-19.

冠状病毒（CoVs）是一种包膜的正义RNA病毒，其特征是从其表面突出的棍棒状刺突，异常大的RNA基因组和独特的复制能力。已知CoV会引起各种潜在的致命人类呼吸道传染病，例如严重急性呼吸道综合症（SARS），中东呼吸综合症（MERS）和最近的2019年冠状病毒病（COVID-19）爆发。不幸的是，迄今为止，尚未批准药物和疫苗来预防和治疗由冠状病毒引起的这些疾病。因此，迫切需要有效的预防和治疗人类冠状病毒的药物。在过去的几十年中，已经报道了许多天然化合物具有多种生物活性，包括抗病毒特性。在这篇文章中，