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Multicomponent Catalytic Synthesis of 1,5-Benzodiazepines: An Update
Mini-Reviews in Organic Chemistry ( IF 2.3 ) Pub Date : 2020-05-01 , DOI: 10.2174/1570193x16666190509074109
Rajesh K. Singh 1 , Sadhna Sharda 2 , Shikha Sharma 3 , Sahil Kumar 4 , Deo Nandan Prasad 1
Affiliation  

1,5-Benzodiazepines are considered some of the most vital classes of heterocyclic compounds due to their amazing biological and varied pharmacological activities. They are regarded as privileged structures and therefore have been striking synthetic targets for organic and medicinal chemists over the last decade. This results in the exploration of various silica supported catalysts, Lewis acids, organoacids, magnetic nanoparticles and other miscellaneous catalysts that have been investigated till date for an efficient and green synthesis of 1,5-benzodiazepine and its derivatives. The current review article primarily covers the one-pot green chemical synthesis of 1,5- benzodiazepines using various novel catalysts. The main motive of this review is the assessment of the literature on various catalysts along with their yield, reaction condition, and mechanism of action. In the end, the entire catalysts are structured systematically into various Lewis acids, Bronsted organoacids, supported catalysts, nanocatalysts, and miscellaneous catalysts and are presented in the form of tables for quick ‘at a glance’ study of catalysts, their reaction condition, time taken, etc.



中文翻译:

1,5-苯二氮卓类化合物的多组分催化合成:最新进展

1,5-苯二氮卓类化合物因其惊人的生物学活性和多种药理活性而被认为是最重要的杂环化合物。它们被视为特权结构,因此在过去十年中一直是有机和药用化学家的合成目标。这导致了对各种二氧化硅负载的催化剂,路易斯酸,有机酸,磁性纳米颗粒和其他各种催化剂的探索,这些催化剂迄今已被研究以有效和绿色地合成1,5-苯并二氮杂及其衍生物。本篇综述文章主要涵盖使用各种新型催化剂的一锅法绿色化学合成1,5-苯并二氮杂ze。这篇综述的主要目的是对各种催化剂及其产率,反应条件,和作用机制。最后,整个催化剂被系统地构造成各种路易斯酸,布朗斯台德有机酸,负载型催化剂,纳米催化剂和其他催化剂,并以表格的形式提供,以快速“一目了然”地研究催化剂,它们的反应条件,时间。采取等

更新日期:2020-05-01
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