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A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps
Frontiers in Neuroinformatics ( IF 3.5 ) Pub Date : 2020-05-19 , DOI: 10.3389/fninf.2020.00022
Tristan Deruelle 1 , Frank Kober 2 , Adriana Perles-Barbacaru 2 , Thierry Delzescaux 3 , Vincent Noblet 4 , Emmanuel L Barbier 1 , Michel Dojat 1
Affiliation  

Similarly to human population imaging, there are several well-founded motivations for animal population imaging, the most notable being the improvement of the validity of statistical results by pooling a sufficient number of animal data provided by different imaging centers. In this paper, we demonstrate the feasibility of such a multicenter animal study, sharing raw data from forty rats and processing pipelines between four imaging centers. As specific use case, we focused on T1 and T2 mapping of the healthy rat brain at 7T. We quantitatively report about the variability observed across two MR data providers and evaluate the influence of image processing steps on the final maps, using three fitting algorithms from three centers. Finally, to derive relaxation times from different brain areas, two multi-atlas segmentation pipelines from different centers were performed on two different platforms. Differences between the two data providers were 2.21% for T1 and 9.52% for T2. Differences between processing pipelines were 1.04% for T1 and 3.33% for T2. These maps, obtained in healthy conditions, may be used in the future as reference when exploring alterations in animal models of pathology.

中文翻译:

多中心临床前 MRI 研究:大鼠脑松弛测量参考图的定义

与人口成像类似,动物种群成像有几个有根据的动机,最显着的是通过汇集不同成像中心提供的足够数量的动物数据来提高统计结果的有效性。在本文中,我们展示了这种多中心动物研究的可行性,在四个成像中心之间共享来自 40 只大鼠的原始数据和处理管道。作为特定用例,我们专注于 7T 下健康大鼠大脑的 T1 和 T2 映射。我们使用来自三个中心的三种拟合算法,定量报告在两个 MR 数据提供者之间观察到的可变性,并评估图像处理步骤对最终地图的影响。最后,为了从不同的大脑区域推导出放松时间,来自不同中心的两个多图谱分割管道在两个不同的平台上执行。两个数据提供者之间的差异为 T1 的 2.21% 和 T2 的 9.52%。处理流水线之间的差异对于 T1 为 1.04%,对于 T2 为 3.33%。这些在健康条件下获得的地图可在未来探索病理动物模型的改变时用作参考。
更新日期:2020-05-19
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