Background: Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease usually affecting children and is treated with high-dose steroid therapy. Case Report: An 8-year boy presented with limbs weakness and complete loss of vision and was resistant to steroid therapy. He was further treated with plasma exchange and showed full recovery from the neurological deficit. Conclusion: Therapeutic plasma exchange appears to be effective in ADEM patients in reversing the neuropathological process especially refractory to steroids and intravenous immunoglobulin.

中文翻译：

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血浆置换在类固醇和 IVIG 难治性急性播散性脑脊髓炎患者中的作用：病例报告

背景：急性播散性脑脊髓炎（ADEM）是一种通常影响儿童的脱髓鞘疾病，采用大剂量类固醇治疗。病例报告：一名 8 岁男孩出现四肢无力和完全丧失视力，并且对类固醇治疗有抵抗力。他进一步接受了血浆置换治疗，并从神经功能缺损中完全恢复。结论：治疗性血浆置换似乎对 ADEM 患者逆转神经病理学过程有效，尤其是对类固醇和静脉注射免疫球蛋白无效。