Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.

中文翻译：

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分子印迹纳米粒子对水中复合糖和糖蛋白的选择性结合。

识别生物聚糖的合成受体非常需要现代糖科学和技术，但是由于碳水化合物在水中的强溶剂化和客体的结构复杂性，它们的设计和合成一直是艰巨的挑战。利用酰胺交联剂在表面活性剂胶束中的分子印迹提供了一种方便的一锅法，可利用表面活性剂/水界面附近的氢键相互作用来制备糖苷，聚糖和糖蛋白的纳米颗粒受体。在水中获得了生物竞争性的微摩尔结合亲和力，并且可以区分出聚糖的细微结构差异。