We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population. We recruited 329 cognitively normal right-handed Han Chinese subjects who completed ApoE gene testing and urinary AD7c-NTP testing. There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups. Urinary AD7c-NTP levels were significantly higher in subjects with ApoE ɛ3/4 and 4/4 [0.6074 (0.6541) ng/mL] than in subjects without ApoE ɛ4 [0.4368 (0.3392) ng/mL and 0.5287 (0.3656) ng/mL], and urinary AD7c-NTP levels positively correlated with ApoE genotype grade (, ). There were significant differences in urinary AD7c-NTP levels between subjects with and without a history of coronary heart disease or diabetes. Urinary AD7c-NTP levels were not related to years of education, nature of work, family history of dementia, a history of hypertension, stroke, anemia, or thyroid dysfunction. Urinary AD7c-NTP levels were positively correlated with ApoE grade in the cognitively normal population. The relationship between risk factors of cognitive decline and urinary AD7c-NTP levels provides a new way for us to understand AD and urinary AD7c-NTP.

中文翻译：

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认知正常人群中尿液阿兹海默症相关神经元线蛋白和载脂蛋白Epsilon 4等位基因之间的关系。

我们调查了认知正常人群中尿液阿尔茨海默病相关神经元线蛋白（AD7c-NTP）水平与载脂蛋白epsilon 4（ApoE E4）等位基因之间的关系，以及引起认知功能下降的其他因素。我们招募了329位认知正常的右手汉族受试者，他们完成了ApoE基因测试和尿液AD7c-NTP测试。正常对照组和主观认知下降组之间的尿AD7c-NTP水平无显着差异。尿AD7C-NTP水平与受试者显著更高的ApoEɛ3/ 4和4/4 [0.6074（0.6541）毫微克/毫升]比的被摄体而不会ApoE基因ɛ4[0.4368（0.3392）ng / mL和0.5287（0.3656）ng / mL]以及尿中AD7c-NTP水平与ApoE基因型等级呈正相关（， ）。有和没有冠心病或糖尿病病史的受试者之间尿AD7c-NTP水平存在显着差异。尿AD7c-NTP水平与受教育年限，工作性质，痴呆症家族史，高血压，中风，贫血或甲状腺功能障碍史无关。在认知正常人群中，尿中AD7c-NTP水平与ApoE等级呈正相关。认知能力下降的危险因素与尿液AD7c-NTP水平之间的关系为我们了解AD和尿液AD7c-NTP提供了新途径。