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Bone-Specific Metabolism of Dietary Polyphenols in Resorptive Bone Diseases.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-06-25 , DOI: 10.1002/mnfr.202000072
Andrew G Kunihiro 1 , Paula B Luis 2 , Jennifer B Frye 3 , Wade Chew 4 , H H Chow 4 , Claus Schneider 2 , Janet L Funk 1, 3
Affiliation  

Curcumin prevents bone loss in resorptive bone diseases and inhibits osteoclast formation, a key process driving bone loss. Curcumin circulates as an inactive glucuronide that can be deconjugated in situ by bone's high β‐glucuronidase (GUSB) content, forming the active aglycone. Because curcumin is a common remedy for musculoskeletal disease, effects of microenvironmental changes consequent to skeletal development or disease on bone curcumin metabolism are explored.

中文翻译:

膳食多酚在骨吸收疾病中的骨特异性代谢。

姜黄素可防止骨吸收疾病中的骨质流失,并抑制破骨细胞的形成,这是导致骨质流失的关键过程。姜黄素以无活性的葡萄糖醛酸苷形式循环,可被骨骼中高含量的 β-葡萄糖醛酸酶 (GUSB) 原位解结合,形成活性糖苷配基。由于姜黄素是治疗肌肉骨骼疾病的常用药物,因此研究了骨骼发育或疾病引起的微环境变化对骨姜黄素代谢的影响。
更新日期:2020-06-25
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