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Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources.
Trends in Analytical Chemistry ( IF 13.1 ) Pub Date : 2020-06-07 , DOI: 10.1016/j.trac.2020.115942
Patrícia Poletto 1 , Gerardo Alvarez-Rivera 2 , Talyta M S Torres 1 , Jose A Mendiola 2 , Elena Ibañez 2 , Alejandro Cifuentes 2
Affiliation  

Many natural compounds, found mainly in plants, are associated with the treatment of various diseases. The search for natural therapeutic agents includes compounds with antiviral and anti-inflammatory activities. Among the many steps involved in bioprospection, extraction is the first and most critical step for obtaining bioactive compounds. One of the main advantages of using compressed fluids extraction is the high quality of the final product obtained due to the use of green solvents, while the selectivity towards target compounds can be tuned by adjusting the process parameters, especially pressure, temperature and solvent characteristics. In this review, a discussion is provided on the power of compressed fluids, such as supercritical fluid extraction (SFE), pressurized liquid extraction (PLE) and subcritical water extraction (SWE) to obtain antiviral and anti-inflammatory compounds from natural sources. In addition, an adequate knowledge about the identity and quantity of the compounds present in the extract is essential to correlate biological activity with chemical composition. Phytochemical profiling tools used for identification and quantification of these bioactive natural compound are also discussed. It can be anticipated that after the current SARS-COV-2 pandemic, the search of new natural compounds with antiviral and anti-inflammatory activity will be a hot research topic, so, this review provides an overview on the technologies currently used that could help this research.



中文翻译:

压缩流体和植物化学分析工具,可从天然来源获得并表征抗病毒和抗炎化合物。

主要存在于植物中的许多天然化合物与各种疾病的治疗有关。寻找天然治疗剂包括具有抗病毒和抗炎活性的化合物。在生物勘探的许多步骤中,提取是获得生物活性化合物的第一步,也是最关键的一步。使用压缩流体萃取的主要优点之一是由于使用绿色溶剂而获得的最终产品的高质量,而对目标化合物的选择性可通过调节工艺参数(尤其是压力,温度和溶剂特性)进行调节。在本文中,我们将讨论压缩流体的动力,例如超临界流体萃取(SFE),加压液体萃取(PLE)和次临界水萃取(SWE)从天然来源获得抗病毒和抗炎化合物。另外,对提取物中存在的化合物的身份和数量的充分了解对于使生物学活性与化学组成相关至关重要。还讨论了用于鉴定和定量这些生物活性天然化合物的植物化学谱分析工具。可以预见,在当前的SARS-COV-2大流行之后,寻找具有抗病毒和抗炎活性的新天然化合物将成为热门研究课题,因此,本综述概述了目前使用的可帮助解决问题的技术。这项研究。对提取物中存在的化合物的身份和数量的充分了解对于使生物学活性与化学组成相关至关重要。还讨论了用于鉴定和定量这些生物活性天然化合物的植物化学谱分析工具。可以预见,在当前的SARS-COV-2大流行之后,寻找具有抗病毒和抗炎活性的新天然化合物将成为热门研究课题,因此,本综述概述了目前使用的可帮助解决问题的技术。这项研究。对提取物中存在的化合物的身份和数量的充分了解对于使生物学活性与化学组成相关至关重要。还讨论了用于鉴定和定量这些生物活性天然化合物的植物化学谱分析工具。可以预见,在当前的SARS-COV-2大流行之后,寻找具有抗病毒和抗炎活性的新天然化合物将成为热门研究课题,因此,本综述概述了目前使用的可帮助解决问题的技术。这项研究。

更新日期:2020-07-07
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