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Frontostriatal white matter connectivity: Age differences and associations with cognition and BOLD modulation
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.neurobiolaging.2020.05.014
Christina E Webb 1 , David A Hoagey 1 , Karen M Rodrigue 1 , Kristen M Kennedy 1
Affiliation  

Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white matter connectivity, and identified associations with both executive function performance and dynamic modulation of blood-oxygen-level-dependent (BOLD) activation to task difficulty in a lifespan sample of 169 healthy humans aged 20-94 years. Greater frontostriatal diffusivity was associated with poorer executive function and this negative association strengthened with increasing age. Whole-brain functional magnetic resonance imaging (fMRI) analyses additionally indicated an association between frontostriatal mean diffusivity and BOLD modulation to difficulty selectively in the striatum across 2 independent fMRI tasks. This association was moderated by age, such that younger- and middle-aged individuals showed reduced dynamic range of difficulty modulation as a function of increasing frontostriatal diffusivity. Together these results demonstrate the importance of age-related degradation of frontostriatal circuitry on executive functioning across the lifespan, and highlight the need to capture brain changes occurring in early-to middle-adulthood.

中文翻译:

额纹状体白质连通性:年龄差异以及与认知和 BOLD 调制的关联

尽管皮质-纹状体回路对认知很重要,但对年龄对连接这些区域的结构回路的​​影响的研究是有限的。目前的研究检查了年龄对额纹状体白质连接的影响,并确定了 169 名 20-94 岁健康人的寿命样本与执行功能表现和血氧水平依赖性 (BOLD) 激活对任务难度的动态调节的关联年。更大的额纹状体扩散性与较差的执行功能相关,这种负相关性随着年龄的增长而加强。全脑功能磁共振成像 (fMRI) 分析还表明,额纹状体平均扩散率和 BOLD 调制之间存在关联,从而在 2 个独立的 fMRI 任务中选择性地在纹状体中遇到困难。这种关联受年龄影响,因此年轻和中年人表现出难度调制的动态范围减小,作为增加额纹状体扩散的函数。这些结果共同证明了与年龄相关的额纹状体回路退化对整个生命周期执行功能的重要性,并强调需要捕捉发生在成年早期到中期的大脑变化。
更新日期:2020-10-01
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