Ultra-small superparamagnetic iron oxide (USPIO) nanoparticles appear to be promising tools for MR lymphography due to their unique magnetic properties. In clinical diagnosis, the effectiveness of USPIO will greatly affect the clinician's judgment to the enhanced MR images. In this study, we evaluated the effectiveness of CS015, a PAA-coated USPIO, with subcutaneous and intravenous administration. It appeared that subcutaneously injected particles had much higher efficiency to reach lymph nodes, and even worked at a very small dose 0.075 μmol/kg. Further, we compared CS015 with ferumoxytol and ferumoxtran-10 in MR lymphography and found that CS015 had the best performance. And the lymph node metastases in New Zealand rabbits were successfully detected using CS015 with one single dose. These merits of CS015 make it a promising MR lymphography contrast agent with potential applications in cancer therapy.

超小型超顺磁性氧化铁（USPIO）纳米颗粒由于其独特的磁性，似乎是有前途的MR淋巴摄影工具。在临床诊断中，USPIO的有效性将极大地影响临床医生对增强型MR图像的判断。在这项研究中，我们评估了皮下注射和静脉内注射CS015（PAA涂层USPIO）的有效性。似乎皮下注射的颗粒具有更高的到达淋巴结的效率，甚至在0.075μmol/ kg的很小剂量下也能起作用。此外，我们在MR淋巴造影中比较了CS015，阿魏酸和ferumoxtran-10，发现CS015具有最佳性能。一剂CS015成功地检测了新西兰兔的淋巴结转移。