Background

Boron is a trace element that plays an important role in numerous biological functions, including calcium metabolism, growth and maintenance of bone tissue. However, there are still no precise indications regarding a possible role of boron supplementation, and its amount of supplementation, to maintain bone health. So the aim of this narrative review was to consider the state of the art on the effectiveness of boron supplementation (alone or with other micronutrients) on growth and maintenance of bone in humans through control of calcium, vitamin D and sex steroid hormone metabolism in order to suggest a daily dosage of boron supplementation.

Main findings

This review included 11 eligible studies: 7 regarding the supplementation with boron alone and 4 regarding supplementation with boron and other nutrients. Despite the number of studies considered being low, the number of subjects studied is high (594) and the results are interesting.

Conclusions

The studies considered in this narrative review have evaluated the positive effectiveness on bone, in humans, through control of calcium, vitamin D and sex steroid hormone metabolism, considering a dietary supplementation of 3 mg/day of boron (alone or with other nutrients); this supplementation is demonstrably useful to support bone health (in order to prevent and maintain adequate bone mineral density), also considering the daily dose of 3 mg is much lower than the Upper Level indicated by EFSA in the daily dose of 10 mg.

中文翻译：

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硼补充剂对骨骼健康的关键作用：叙述性评论。

背景

硼是一种微量元素，在许多生物功能中起着重要作用，包括钙代谢、骨组织的生长和维持。然而，关于硼补充剂及其补充量对维持骨骼健康的可能作用，仍然没有确切的迹象。因此，这篇叙述性综述的目的是通过控制钙、维生素 D 和性类固醇激素的代谢来考虑补充硼（单独或与其他微量营养素一起）对人类骨骼生长和维持的有效性的最新技术水平。建议每日补充硼的剂量。

主要发现

该评价包括 11 项符合条件的研究：7 项关于单独补充硼，4 项关于补充硼和其他营养素。尽管被认为的研究数量很少，但研究对象的数量却很高（594）并且结果很有趣。

结论

本叙述性综述中考虑的研究评估了通过控制钙、维生素 D 和性类固醇激素代谢对人体骨骼的积极效果，考虑到膳食补充剂 3 毫克/天的硼（单独或与其他营养素一起）；这种补充剂明显有助于支持骨骼健康（以预防和维持足够的骨矿物质密度），同时考虑到 3 毫克的每日剂量远低于 EFSA 指示的每日剂量 10 毫克的上限。