Background

Studies in western populations find that obesity and depression are positively correlated. Adipokines secreted by adipose tissue may serve as the crosstalk link between peripheral tissue and central nervous system, which mediates the relationship between obesity and depression.

Objective

This study aimed to investigate serum retinol-binding protein 4 (RBP4) concentration in patients with major depressive depression (MDD) and clarify its possible association with depression.

Methods

Major depressive disorder patients (n = 237), healthy controls (n = 48) were collected from June 2017 to October 2019. The measurement of RBP4 levels was performed by Advia 2400 automatic biochemistry analyzer. Depressive symptoms of patients were assessed using the 24-item Hamilton Depression Scale (HAMD-24).

Results

(1) Serum RBP4 levels of MDD patients were significantly lower than that of the control group [(34.25 ± 8.82) mg/L vs (37.56 ± 8.83) mg/L] (P < 0.05) which was independent from obesity; (2) The level of RBP4 [(31.13 ± 9.16) mg/L] in suicide attempt (SA) group was significantly lower than that in the control group and non-suicide attempt (non-SA) group [(35.55 ± 8.37)mg/L](P < 0.05); (3) There was no significant correlation between serum RBP4 concentration and HAMD-24 score (P > 0.05); serum RBP4 concentrations were positively associated with age, age of onset and duration of disease (r = 0.325, 0.298, 0.135; P < 0.001, P < 0.001, P = 0.038) in depressive patients. (4) The level of serum RBP4 was positively correlated with TC, TG, and LDL-C (r = 0.350, 0.207, 0.268; P < 0.001, P = 0.001, P < 0.001), but not with other blood lipid indexes. ROC curve of RBP4 for MDD revealed an area under the curve of 0.603 and a sensitivity of 81.3%, specificity of 80%.

Conclusion

The level of RBP4 in patients with MDD was lower than that in the normal control group, which might be related to the prognosis of patients with depression.

中文翻译：

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重度抑郁症患者血清视黄醇结合蛋白 4 水平降低的研究。

背景

对西方人群的研究发现，肥胖与抑郁呈正相关。脂肪组织分泌的脂肪因子可作为外周组织与中枢神经系统之间的串扰联系，介导肥胖与抑郁之间的关系。

客观的

本研究旨在调查重度抑郁症 (MDD) 患者的血清视黄醇结合蛋白 4 (RBP4) 浓度，并阐明其与抑郁症的可能关联。

方法

于 2017 年 6 月至 2019 年 10 月收集重度抑郁症患者 (n = 237)、健康对照组 (n = 48)。RBP4 水平的测量采用 Advia 2400 自动生化分析仪进行。使用 24 项汉密尔顿抑郁量表 (HAMD-24) 评估患者的抑郁症状。

结果

（1）MDD患者血清RBP4水平显着低于对照组[（34.25±8.82）mg/L vs（37.56±8.83）mg/L]（P  <0.05），与肥胖无关；(2)自杀未遂(SA)组RBP4[(31.13±9.16)mg/L]水平显着低于对照组和非自杀未遂(non-SA)组[(35.55±8.37)毫克/升]( P  < 0.05); (3)血清RBP4浓度与HAMD-24评分无显着相关性( P  >0.05)；血清 RBP4 浓度与年龄、发病年龄和病程呈正相关（r  = 0.325、0.298、0.135；P  < 0.001、P  < 0.001、P = 0.038) 在抑郁症患者中。(4)血清RBP4水平与TC、TG、LDL-C呈正相关( r  =0.350、0.207、0.268；P  <0.001、P  =0.001、P  <0.001)，而与其他血脂指标不相关。RBP4 对 MDD 的 ROC 曲线显示曲线下面积为 0.603，敏感性为 81.3%，特异性为 80%。

结论

MDD患者的RBP4水平低于正常对照组，这可能与抑郁症患者的预后有关。