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A behavioral method to estimate charge integration efficiency in cochlear implant users.
Journal of Neuroscience Methods ( IF 3 ) Pub Date : 2020-06-06 , DOI: 10.1016/j.jneumeth.2020.108802
Ning Zhou 1 , Lixue Dong 1 , John J Galvin 2
Affiliation  

Background

In cochlear implants, pulse amplitude (PA) or pulse phase duration (PPD) can be used to increase loudness. Loudness grows more slowly with increasing PPD, resulting in a larger dynamic range (DR), possibly reflecting “leaky” charge integration associated with neural degeneration due to hearing loss. Here, we propose a method to estimate charge integration efficiency for CI users.

New method

The DR was measured with increasing PA or PPD, relative to a common threshold anchor with a short PPD (25μs/ph); DRs were converted to the common unit of charge (nC). Charge integration efficiency was calculated as the dB difference in DR with increasing PPD or PA. Loudness growth functions were also compared as PA or PPD was increased relative to the common threshold.

Results

Ten CI ears were tested; all participants were adult users of Cochlear© devices. DR was significantly larger when PPD was increased, requiring (on average) 70 % more charge than when PA was increased. A significant correlation (p = 0.007) was observed between duration of deafness and charge integration efficiency, largely driven by a participant with long auditory deprivation in both ears. Loudness growth was slower when PPD was increased, consistent with previous studies.

Comparison to Existing Methods. The present method offers a quick behavioral test with which to measure charge integration efficiency, which may be a useful measure of neural health.

Discussion

Charge integration efficiency may be used to probe neural health independent of absolute detection thresholds, which mostly reflect the proximity of electrodes to neural populations.



中文翻译:

一种估计耳蜗植入用户中电荷整合效率的行为方法。

背景

在人工耳蜗中,可以使用脉冲幅度(PA)或脉冲相位持续时间(PPD)来增加响度。随着PPD的增加,响度的增长速度会更慢,从而导致更大的动态范围(DR),这可能反映出与听力损失引起的神经变性相关的“泄漏”电荷整合。在这里,我们提出了一种估算CI用户费用整合效率的方法。

新方法

相对于具有短PPD(25μs/ ph)的常见阈值锚点,通过增加PA或PPD测量DR。DR已转换为通用计费单位(nC)。电荷积分效率计算为DR随PPD或PA增大的dB差异。当PA或PPD相对于常见阈值增加时,响度增长功能也进行了比较。

结果

测试了十只CI耳朵;所有参与者均为Cochlear©设备的成人用户。当PPD增加时,DR明显更大,平均需要比PA增加时多70%的电荷。耳聋持续时间与电荷整合效率之间存在显着相关性(p = 0.007),这在很大程度上是由双耳长期听觉剥夺的参与者所驱动。当PPD增加时,响度增长较慢,这与以前的研究一致。

与现有方法的比较。本方法提供了一种快速的行为测试,可用来测量电荷积分效率,这可能是神经健康的一种有用方法。

讨论区

电荷积分效率可用于独立于绝对检测阈值来探测神经健康,绝对检测阈值主要反映电极与神经种群的接近程度。

更新日期:2020-06-06
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