Allergic asthma, which is the most common type of asthma, is mediated by the IgE response, and B cells are key drivers of allergic inflammation in the lungs. B cell activation factor (BAFF) and proliferation inducing ligand (APRIL) are members of the TNF superfamily. BAFF and APRIL interact with three receptors, namely the B cell activation factor receptor (BAFF-r), B cell maturation antigen (BCMA), and transmembrane activator; calcium modulator; and cyclophilin ligand interactor (TACI). The interaction of BAFF and APRIL with their receptors induces B cell activation, differentiation, and antibody production. BAFF and APRIL are produced by airway epithelial cells during the response to allergens or infectious agents, and have shown to induce local IgE production, thus establishing allergic inflammation in the airways. BAFF can maintain in inflamed airways during infection and can inhibit regulatory T cells (Tregs), thereby promoting allergic inflammation in the airways. This review aims to outline current knowledge about BAFF/APRIL systems in humans as well as in murine models of allergic asthma. The precise role of BAFF and APRIL and their receptors in allergic asthma remains unclear. Therefore, further studies are required to identify and elucidate their roles in enhancing IgE production and activating immune cells that drive the Th2 effector response and initiate allergic inflammation in asthma. Targeting BAFF/APRIL or their cognate receptors may offer a novel therapeutic approach in asthma treatment.

过敏性哮喘是最常见的哮喘类型，由IgE反应介导，而B细胞是肺部过敏性炎症的关键驱动因素。B细胞激活因子（BAFF）和增殖诱导配体（APRIL）是TNF超家族的成员。BAFF和APRIL与三种受体相互作用，即B细胞激活因子受体（BAFF-r），B细胞成熟抗原（BCMA）和跨膜激活剂。钙调节剂 和亲环蛋白配体相互作用物（TACI）。BAFF和APRIL及其受体的相互作用可诱导B细胞活化，分化和抗体产生。BAFF和APRIL是在对过敏原或传染原反应期间由气道上皮细胞产生的，并且已显示出诱导局部IgE产生，从而在气道中产生过敏性炎症。BAFF可以在感染过程中维持发炎的气道，并可以抑制调节性T细胞（Tregs），从而促进气道的过敏性炎症。这篇综述旨在概述有关人类以及过敏性哮喘小鼠模型中BAFF / APRIL系统的当前知识。尚不清楚BAFF和APRIL及其受体在过敏性哮喘中的确切作用。因此，需要进一步的研究来鉴定和阐明其在增强IgE产生和激活免疫细胞中的作用，所述免疫细胞驱动Th2效应子反应并引发哮喘的过敏性炎症。靶向BAFF / APRIL或其同源受体可能为哮喘治疗提供一种新颖的治疗方法。这篇综述旨在概述有关人类以及过敏性哮喘小鼠模型中BAFF / APRIL系统的当前知识。尚不清楚BAFF和APRIL及其受体在过敏性哮喘中的确切作用。因此，需要进一步的研究来鉴定和阐明其在增强IgE产生和激活免疫细胞中的作用，所述免疫细胞驱动Th2效应子反应并引发哮喘的过敏性炎症。靶向BAFF / APRIL或其同源受体可能为哮喘治疗提供一种新颖的治疗方法。这篇综述旨在概述有关人类以及过敏性哮喘小鼠模型中BAFF / APRIL系统的当前知识。尚不清楚BAFF和APRIL及其受体在过敏性哮喘中的确切作用。因此，需要进一步的研究来鉴定和阐明其在增强IgE产生和激活免疫细胞中的作用，所述免疫细胞驱动Th2效应子反应并引发哮喘的过敏性炎症。靶向BAFF / APRIL或其同源受体可能为哮喘治疗提供一种新颖的治疗方法。需要进一步的研究来鉴定和阐明其在增强IgE产生和激活免疫细胞中的作用，这些免疫细胞驱动Th2效应子反应并引发哮喘的过敏性炎症。靶向BAFF / APRIL或其同源受体可能为哮喘治疗提供一种新颖的治疗方法。需要进一步的研究来鉴定和阐明其在增强IgE产生和激活免疫细胞中的作用，这些免疫细胞驱动Th2效应子反应并引发哮喘的过敏性炎症。靶向BAFF / APRIL或其同源受体可能为哮喘治疗提供一种新颖的治疗方法。