Chlorpyrifos is an extensively used organophosphate pesticide showing broad-spectrum effectiveness on various target pests. Long-term sublethal exposure to this pesticide is reported to produce detrimental effects on sex hormone metabolism and nervous system functioning. It is a suspected endocrine-disrupting chemical and causes abnormal developmental patterns, gonadal atrophy, and neurodevelopmental problems. The degradation products formed during environmental degradation of chlorpyrifos are also capable of binding with steroid hormone receptors such as estrogen receptor alpha (ER-α) and can disrupt estrogen signaling in humans. In the present study, chlorpyrifos and four of its degradation products viz. CPYO, DEC, TCP, and TMP were chosen to study their ability to bind with estrogen receptors. The molecular docking and dynamics simulation carried out to understand the molecular interaction of chlorpyrifos and its environmental degradation products with human ER reveal the risk of potential disruption in estrogen signaling in humans by these compounds.

中文翻译：

---

内分泌干​​扰：毒死蜱及其降解产物与雌激素受体的分子相互作用

毒死蜱是一种广泛使用的有机磷农药，对多种目标害虫表现出广谱效果。据报道，长期亚致死接触这种杀虫剂会对性激素代谢和神经系统功能产生不利影响。它是一种可疑的内分泌干扰化学物质，会导致异常发育模式、性腺萎缩和神经发育问题。在毒死蜱环境降解过程中形成的降解产物也能够与类固醇激素受体结合，例如雌激素受体 α (ER-α)，并可以破坏人体的雌激素信号。在本研究中，毒死蜱及其四种降解产物即。选择 CPYO、DEC、TCP 和 TMP 来研究它们与雌激素受体结合的能力。