SMAD2 is a critical signal transducer molecule in the TGFβ- SMAD pathway which is also known for its tumor suppressor role. Genetic variations in SMAD2 render cells insensitive to its anti-proliferative signals leading to tumor formation. In this study, we demonstrate the impact of single nucleotide polymorphisms (SNPs) of SMAD2 (rs4940086 and rs8085335) on cervical cancer risk development in Bangladeshi population. 132 cervical cancer patients and 98 control volunteers were enrolled in the study and genotyped utilizing polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method. The association between cervical cancer susceptibility and the chosen SNPs were evaluated through multiple logistic regression. SMAD2 rs4940086 heterozygous genotype (T/C) was associated with a 3.89 times higher risk of cervical cancer development (P = 0.001, AOR 3.89, 95% CI 1.777–8.513). The T/C and C/C genotypes in combination also significantly elevated cervical cancer risk (P = 0.035, AOR 1.876, 95% CI 1.047–3.364). Urban cancer patients had a significantly higher chance of carrying the rs4940086 polymorphism as compared to rural cancer patients (P = 0.045, OR 2.59 95% CI 1.02–6.59). SMAD2 rs8085335 heterozygous variant (A/G) demonstrated modest effects in increasing cervical cancer susceptibility (P = 0.594, AOR 1.247, 95% CI 0.554–2.809). Our results suggest that polymorphic variations in SMAD2, particularly rs4940086, can potentially elevate cervical cancer susceptibility in Bangladeshi women.

SMAD2是TGFβ-SMAD途径中的关键信号转导分子，也以其抑癌作用而闻名。SMAD2的遗传变异使细胞对其导致肿瘤形成的抗增殖信号不敏感。在这项研究中，我们证明了SMAD2（rs4940086和rs8085335）的单核苷酸多态性（SNP）对孟加拉国人群宫颈癌风险的发展。132名宫颈癌患者和98名对照志愿者参加了研究，并使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法进行基因分型。宫颈癌易感性与选择的SNPs之间的关联通过多元logistic回归进行评估。SMAD2rs4940086杂合基因型（T / C）与宫颈癌发生风险高3.89倍相关（P = 0.001，AOR 3.89，95％CI 1.777–8.513）。T / C和C / C基因型的组合也显着提高了子宫颈癌的风险（P = 0.035，AOR 1.876，95％CI 1.047-3.364）。与农村癌症患者相比，城市癌症患者具有rs4940086多态性的机会要高得多（P = 0.045，或2.59 95％CI 1.02-6.59）。SMAD2 rs8085335杂合变体（A / G）在增加宫颈癌易感性方面显示出适度的作用（P = 0.594，AOR 1.247，95％CI 0.554-2.809）。我们的结果表明，SMAD2的多态性变异，尤其是rs4940086，可能会提高孟加拉国妇女的宫颈癌易感性。