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Synthetic biology in various cellular and molecular fields: applications, limitations, and perspective.
Molecular Biology Reports ( IF 2.8 ) Pub Date : 2020-06-07 , DOI: 10.1007/s11033-020-05565-6
Mohsen Safaei 1 , Gholam-Reza Mobini 2 , Ardavan Abiri 3 , Ali Shojaeian 4
Affiliation  

Synthetic biology breakthroughs have facilitated genetic circuit engineering to program cells through novel biological functions, dynamic gene expressions, as well as logic controls. SynBio can also participate in the rapid development of new treatments required for the human lifestyle. Moreover, these technologies are applied in the development of innovative therapeutic, diagnostic, as well as discovery-related methods within a wide range of cellular and molecular applications. In the present review study, SynBio applications in various cellular and molecular fields such as novel strategies for cancer therapy, biosensing, metabolic engineering, protein engineering, and tissue engineering were highlighted and summarized. The major safety and regulatory concerns about synthetic biology will be the environmental release, legal concerns, and risks of the engineered organisms. The final sections focused on limitations to SynBio.



中文翻译:

各种细胞和分子领域的合成生物学:应用、局限性和前景。

合成生物学的突破促进了基因电路工程通过新的生物功能、动态基因表达以及逻辑控制对细胞进行编程。SynBio 还可以参与人类生活方式所需的新疗法的快速开发。此外,这些技术在广泛的细胞和分子应用中应用于创新治疗、诊断以及发现相关方法的开发。在本综述研究中,强调和总结了 SynBio 在癌症治疗、生物传感、代谢工程、蛋白质工程和组织工程等新策略等细胞和分子领域的应用。合成生物学的主要安全和监管问题将是环境释放、法律问题、和工程生物体的风险。最后几节重点介绍了 SynBio 的局限性。

更新日期:2020-06-07
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