Multi and comprehensive two-dimensional gas chromatography application have been increasingly mentioned in different countries. This technique increases the efficiency of peak separation in chromatographic analysis, minimizing problems due to the presence of interfering compounds in the analysis, especially in complex matrices. In Latin America, it has been applied to different areas of study. However, biological samples have been reported in a small number of applications. This mini-review addresses studies where the multi and comprehensive two-dimensional gas chromatography technique have been applied to biological samples’ analyses. Biological matrices are generally complex, and sample preparation usually requires a large number of steps to minimize potential interferences. The main areas of study described were related to doping control analysis and biomarker analysis. The urine sample was the main type of biological sample used in the studies. Studies have shown that results obtained by two-dimensional gas chromatography or supported or not by mathematical tools allow high efficiency in solving problems such as coelution. However, the small number of works published with the participation of Latin American researchers indicate that equipment price, especially when mass spectrometry is used as a detector, has a limiting factor in its wide application.

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使用多维综合二维气相色谱法在拉丁美洲进行生物分析的前景：小型综述

多面综合二维气相色谱应用在不同国家越来越多地被提及。该技术提高了色谱分析中峰分离的效率，最大限度地减少了由于分析中存在干扰化合物而引起的问题，尤其是在复杂基质中。在拉丁美洲，它已被应用于不同的研究领域。然而，在少数应用中已经报道了生物样品。这篇小型综述讨论了将多维综合二维气相色谱技术应用于生物样品分析的研究。生物基质通常很复杂，样品制备通常需要大量步骤以尽量减少潜在的干扰。所描述的主要研究领域与兴奋剂控制分析和生物标志物分析有关。尿液样本是研究中使用的主要生物样本类型。研究表明，二维气相色谱法获得的结果或数学工具支持或不支持的结果可以高效解决共流出等问题。然而，拉美研究人员参与发表的少数作品表明，设备价格，尤其是质谱作为检测器时，是其广泛应用的限制因素。研究表明，二维气相色谱法获得的结果或数学工具支持或不支持的结果可以高效解决共流出等问题。然而，拉美研究人员参与发表的少数作品表明，设备价格，尤其是质谱作为检测器时，是其广泛应用的限制因素。研究表明，二维气相色谱法获得的结果或数学工具支持或不支持的结果可以高效解决共流出等问题。然而，拉美研究人员参与发表的少数作品表明，设备价格，尤其是质谱作为检测器时，是其广泛应用的限制因素。