The possibility of 3D printing high temperature and chemically resistant polymers creates opportunities for applications in flow chemistry. Herein we describe the development of milli- and microfluidic reactors made of polyether ether ketone (PEEK) with a high temperature 3D printer and examine their mixing performance and suitability for flow reactions at elevated temperatures. Additionally, we present a 3D-printed separator, back pressure regulator and continuous syringe pump, which provide a complete flow system for a fraction of the cost of commercially available flow equipment. Different 3D printed mixing geometries were tested and the influence of mixing on fluorination of a ribose derivative was evaluated. To demonstrate the usability of our self-made flow equipment we performed a multistep reaction of a ribose derivative in excellent yield which could be used as a precursor for the synthesis of nucleoside anti-cancer drugs.

中文翻译：

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3D打印的PEEK反应器以及用于化学合成的完整连续流系统的开发

3D打印耐高温和耐化学性聚合物的可能性为流化学中的应用创造了机会。在这里，我们描述了由聚醚醚酮（PEEK）制成的微流体反应器和微流体反应器与高温3D打印机的开发，并考察了它们的混合性能以及在高温下对流动反应的适用性。此外，我们还提供了3D打印的分离器，背压调节器和连续注射泵，它们可提供完整的流量系统，而成本仅为市售流量设备的一小部分。测试了不同的3D打印混合几何形状，并评估了混合对核糖衍生物氟化的影响。