Pneumocystis jirovecii and microsporidia species are recognized as opportunistic infectious pathogens in AIDS patients. Coinfection of both in one patient has been rarely reported. The aim of the present study was to investigate the coinfection of P. jirovecii and microsporidia in different tissues from AIDS deceased patients. Post mortem histological finding of P. jirovecii and microsporidia was demonstrated by means of the Grocott's methenamine silver and Brown Brenn staining, respectively. Molecular technique was used for identification and characterization of both fungi. Out of the 514 autopsied cases P. jirovecii and microsporidia species were identified in 53 (10.3%) and 62 (12.1%) cases respectively. A total of five cases (0.97%) coinfected with Pneumocystis and microsporidia were recovered from all analyzed autopsies. Coinfection of Pneumocystis and microsporidia is very challenging and raises interesting issues about host-parasite relationship. The early diagnosis of both pathogens must be crucial to establish correct and early treatments, improve the patient's evolution, reducing the risk of death.

中文翻译：

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吉氏肺孢子虫和微孢子虫：HIV病人中异常的共感染？

吉氏肺孢子虫和微孢子虫种类被认为是艾滋病患者中的机会性感染病原体。很少有患者同时感染两种病毒。本研究的目的是调查艾滋病死者不同组织中的吉氏疟原虫和微孢子虫的共感染。验尸组织学发现P.卡氏肺囊虫和小孢子由Grocott的乌洛托品银的手段和布朗布雷恩染色，分别证实。分子技术用于两种真菌的鉴定和表征。走出514尸检病例P.卡氏肺囊虫分别发现了53例（10.3％）和62例（12.1％）的小孢子虫。从所有分析过的尸检中共发现5例（0.97％）合并肺孢子虫和微孢子虫感染的病例。肺孢子虫和微孢子虫的合并感染非常具有挑战性，并提出了有关宿主-寄生虫关系的有趣问题。这两种病原体的早期诊断对于建立正确的早期治疗，改善患者的病情发展，降低死亡风险至关重要。