The effect of metformin vs placebo on sex hormones in CCTG MA.32.,Journal of the National Cancer Institute

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The effect of metformin vs placebo on sex hormones in CCTG MA.32.
Journal of the National Cancer Institute ( IF 10.3 ) Pub Date : 2020-06-04 , DOI: 10.1093/jnci/djaa082
Isabel Pimentel ₁ , Bingshu E Chen ₂ , Ana Elisa Lohmann ₃ , Marguerite Ennis ₄ , Jennifer Ligibel ₅ , Lois Shepherd ₆ , Dawn L Hershman ₇ , Timothy Whelan ₈ , Vuk Stambolic ₉ , Ingrid Mayer ₁₀ , Timothy Hobday ₁₁ , Julie Lemieux ₁₂ , Alastair Thompson ₁₃ , Priya Rastogi ₁₄ , Karen Gelmon ₁₅ , Daniel Rea ₁₆ , Manuela Rabaglio ₁₇ , Susan Ellard ₁₈ , Mihaela Mates ₁₉ , Philippe Bedard ₉ , Lacey Pitre ₂₀ , Theodore Vandenberg ₂₁ , Ryan J O Dowling ₉ , Wendy Parulekar ₂₂ , Pamela J Goodwin ₂₃

Affiliation

Vall d`Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Canadian Cancer Trials Group, Queen's University-Cancer Research Institute, Kingston, ON, Canada.
University of Western Ontario, London, ON, Canada.
Applied Statistician, Markham, ON, Canada.
Dana-Farber Cancer Institute, Boston, MA, USA.
Canadian Cancer Trials Group, Queen's University-Cancer Research Institute, Kingston, ON, Canada.
Herbert Irving Cancer Center, Columbia University, New York, NY, USA.
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, ON, Canada.
University Health Network, Princess Margaret Hospital, Toronto, ON, Canada.
Vanderbilt University, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Mayo Clinic, Rochester, MN, USA.
CHA-Hopital Du St-Sacrement, Hopital Enfant Jesus Site, Quebec City, Canada.
Baylor College of Medicine, Houston, TX, USA.
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA.
BCCA-Vancouver Cancer Centre, Vancouver, BC, Canada.
Institute of Cancer Research, Clinical Trials and Statistics Unit, Sutton, UK.
IBCSG Coordinating Centre, Bern, Switzerland.
BCCA-Cancer Centre for the Southern Interior, Kelowna, BC, Canada.
Cancer Centre of Southeastern Ontario, Kingston, ON, Canada.
Health Sciences North, Sudbury, ON, Canada.
London Regional Cancer Program, London, ON, Canada.
Canadian Cancer Trials Group , Queen's University-Cancer Research Institute, Kingston, ON, Canada.
Lunenfeld Tanenbaum Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Metformin has been associated with lower breast cancer risk and improved outcomes in observational studies. Multiple biologic mechanisms have been proposed, including a recent report of altered sex hormones (SHs). We evaluated the effect of metformin on SHs in MA.32, a phase III trial of nondiabetic BC subjects randomized to metformin or placebo.

中文翻译：

CCTG MA.32 中二甲双胍与安慰剂对性激素的影响。

在观察性研究中，二甲双胍与降低乳腺癌风险和改善预后相关。人们已经提出了多种生物学机制，包括最近关于性激素（SH）改变的报告。我们在 MA.32 中评估了二甲双胍对 SH 的影响，这是一项随机接受二甲双胍或安慰剂的非糖尿病 BC 受试者的 III 期试验。

更新日期：2020-06-04

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