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Clone wars: cells competing to win.
Nature Reviews Genetics ( IF 42.7 ) Pub Date : 2020-06-05 , DOI: 10.1038/s41576-020-0256-6
Dorothy Clyde 1
Affiliation  

During ageing, many normal human tissues become a patchwork of mutant clones. Colom et al. show that, in mutagenized mouse oesophageal epithelium, this mutational landscape arises through cell competition, with clone fitness determined by the genotype of their neighbours.

中文翻译:

克隆人战争:细胞竞争获胜。

在衰老过程中,许多正常的人体组织变成了突变克隆的拼凑而成。科洛姆等人。表明,在诱变的小鼠食管上皮细胞中,这种突变景观是通过细胞竞争产生的,克隆适应度由其邻居的基因型决定。
更新日期:2020-06-05
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