Abstract

Background: We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers.

Materials and methods: T2DM was induced by streptozotocin (50 mg/kg body weight) and high carbohydrate and fat diet (HCFD). The protective group was put on resveratrol (30 mg/kg) 14 days prior to the induction of diabetes and continued on resveratrol and HCFD until being sacrificed at week 12.

Results: Diabetic rats showed a substantial damage to the knee joints and loss of proteoglycans from the articular cartilage, which were effectively but not completly protected by resveratrol. Resveratrol also significantly (p ≤ .0029) reduced diabetic up-regulation of HbA1c, hyperlipidaemia, inflammation and oxidative stress.

Conclusions: Resveratrol protects against T2DM-induced OA associated with the inhibition of glycated haemoglobin, dyslipidemia, and biomarkers of oxidative stress and inflammation.

摘要

背景：我们研究了抗炎和抗氧化剂白藜芦醇是否可以抑制大鼠 2 型糖尿病 (T2DM) 诱导的骨关节炎 (OA)，以及它是否与抑制血糖、血脂异常以及炎症和氧化应激生物标志物有关。

材料与方法：链脲佐菌素（50 mg/kg 体重）和高碳水化合物和高脂肪饮食（HCFD）诱导 T2DM。保护组在诱导糖尿病前 14 天服用白藜芦醇 (30 mg/kg)，并继续服用白藜芦醇和 HCFD，直到第 12 周处死。

结果：糖尿病大鼠表现出对膝关节的严重损伤和关节软骨中蛋白多糖的损失，白藜芦醇有效但不能完全保护这些关节软骨。白藜芦醇还显着 ( p  ≤ .0029) 降低了糖尿病患者 HbA1c、高脂血症、炎症和氧化应激的上调。

结论：白藜芦醇可预防与抑制糖化血红蛋白、血脂异常以及氧化应激和炎症的生物标志物相关的 T2DM 诱导的 OA。