A simple method to prepare azaarenesulfonyl chlorides by NaClO2-mediated oxidative chlorination of azaarenethiols have been developed, with water as the solvent. Easy purification by simple extraction and concentration gives the products in good yields. The azaarenesulfonyl chlorides readily undergo condensation with chiral amines to afford chiral sulfonamides. GRAPHICAL ABSTRACT

中文翻译：

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NaClO2介导的吡啶-2-磺酰氯的制备及手性磺酰胺的合成

开发了一种以水为溶剂，通过 NaClO2 介导的氮杂芳烃硫醇氧化氯化制备氮杂芳烃磺酰氯的简单方法。通过简单的提取和浓缩，容易纯化得到高产率的产品。氮杂芳烃磺酰氯易于与手性胺缩合得到手性磺酰胺。图形概要