ABSTRACT There are several clinicopathological factors associated with the prognosis of cutaneous squamous cell carcinomas (cSCC), but there remains a lack of molecular markers associated with cSCC tumor progression. This study aimed to determine the association between histopathological prognostic parameters and tumoral podoplanin expression in cSCC. This study included 63 paraffin embedded cSCC samples that were evaluated for tumoral podoplanin expression using immunohistochemistry. Among the 63 tumor samples, 27% lacked podoplanin expression, 22% exhibited diffuse podoplanin expression, and 51% exhibited focal podoplanin expression. Tumoral podoplanin expression was correlated with lymphovascular invasion and lymph node metastasis (p value < 0.05, for both). Additional research is needed to further delineate how the tumoral podoplanin expression can be used as a prognostic marker in patients with cSCC.

中文翻译：

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Podoplanin在皮肤鳞状细胞癌中的表达及其与组织病理学预后因素的关系

摘要 有几种临床病理因素与皮肤鳞状细胞癌 (cSCC) 的预后相关，但仍然缺乏与 cSCC 肿瘤进展相关的分子标志物。本研究旨在确定组织病理学预后参数与 cSCC 中肿瘤足蛋白表达之间的关联。该研究包括 63 个石蜡包埋的 cSCC 样本，这些样本使用免疫组织化学评估了肿瘤足蛋白表达。在 63 个肿瘤样本中，27% 缺乏 podoplanin 表达，22% 表现出弥漫性 podoplanin 表达，51% 表现出局灶性 podoplanin 表达。肿瘤足蛋白表达与淋巴血管浸润和淋巴结转移相关（两者的p值均<0.05）。