Introduction

Point-of-care (POC) tests for Neisseria gonorrhoeae (Ng) are urgently needed to control the gonorrhea epidemic, so patients can receive immediate diagnoses and treatment. While the advent of nucleic acid amplification tests (NAATs) has improved the accuracy of Ng identification, very few POC assays are able to provide results of such tests at the clinical visit. Additionally, antimicrobial resistance (AMR) presents a unique treatment challenge for Ng.

Areas covered

This review notes that older POC tests have lower sensitivity for Ng, compared to the currently-available NAATs, and are not adequate for the current demand for high sensitivity. Promising newer assays, which can be used at the POC are covered. This review also includes data about clinicians’ and patients’ acceptability and expectations of POC tests for Ng, testing of extragenital specimens, pooling studies, as well as their impact clinically, and use in low-resource settings.

Expert opinion

The ability to use POC tests to identify and immediately treat Ng infections at the patient encounter offers many benefits and opportunities. POC tests for Ng are currently available, but not widely used especially in low-resource settings. Further development of POC tests with AMR testing capacity is needed to help guide antimicrobial stewardship.

中文翻译：

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逐点进展：淋病护理点测试。

介绍

急需对淋病奈瑟菌(Ng) 进行即时(POC) 检测以控制淋病流行，以便患者能够立即得到诊断和治疗。虽然核酸扩增测试 (NAAT) 的出现提高了 Ng 鉴定的准确性，但很少有 POC 分析能够在临床访问时提供此类测试的结果。此外，抗菌素耐药性 (AMR) 对 Ng 提出了独特的治疗挑战。

覆盖区域

该评论指出，与当前可用的 NAAT 相比，较旧的 POC 测试对 Ng 的灵敏度较低，并且不足以满足当前对高灵敏度的需求。涵盖了可在 POC 中使用的有前途的更新检测方法。本综述还包括有关临床医生和患者对 POC 检测 Ng、生殖器外标本检测、合并研究及其临床影响和在资源匮乏环境中使用的可接受性和期望的数据。

专家意见

在患者遭遇时使用 POC 测试来识别和立即治疗 Ng 感染的能力提供了许多好处和机会。Ng 的 POC 测试目前可用，但并未广泛使用，尤其是在资源匮乏的环境中。需要进一步开发具有 AMR 测试能力的 POC 测试，以帮助指导抗菌药物管理。